Every historical period has had its epidemic executioner, and it has almost always been the ecological changes between human communities and the environment that have caused changes in pathogenicity and epidemic diseases.

«Detailed evidence shows that Nietzsche passed through each of the three stages: the chancre of primary syphilis; the terrible pox, fever and pain of secondary syphilis; and the dreaded third, paresis» In the foothills of the Italian Alps, on a snow-draped piazza in Turin, on January